Brain site of action of trace elements (I): Role of Se in the accumbens nucleus of the rat.

RATTI SG; OROZCO AA; ALVAREZ EO

Mar del P¨lata

Congreso; LXI Reunión Anual de la SAIC, Mar del Plata 16 - 19 Noviembre 2016.; 2016

SAIC

Previously in our laboratory, evidence was presented showing that after systemic administration of Te in non-toxic doses to pregnant mother and its litter rats, several behavioural parameters related to motivated and lateralized exploration in the offspring were affected. Administration of systemic Se simultaneously with Te, blocking of Te effects was found. Since this evidence suggested a central site of action in the brain, the purpose of the present work was to study the possible neural structures involved in the behavioural effects of trace elements. For this purpose, adult male rats were implanted with microinjection cannulae into the accumbens nuclei (left and right), and 48h later, they were injected with 1μl of saline or Na2O3Se (0.17 ng/L) into the left (ACCL; n=10), right (ACCR; n=15) or both neural structures (n=11) at 12:00h for three days. At four day, all animals were tested individually in a general motor activity detector (OVM) and in a Double Lateral Hole-Board Labyrinth (DHBL) to register general, motivated exploratory activity, and lateralized exploration induced by novelty. Results shown that in the OVM, stimulation of the ACCR significantly inhibited head-dipping (5±1 Counts/5min Vs. 14.5±1 Counts/5min; Se Vs. Control, p