Efecto de aliáceas sobre el estrés oxidativo y la inflamación en un modelo experimental de síndrome metabólico.

VAZQUEZ MA; RENNA NF; CACCIAMANI V; GONZALEZ S; LAMA C; MIATELLO RM

Centro de Congresos y Exposiciones "Gobernador Emilio Civit", 5, 6 y 7 de diciembre. Mendoza

Jornada; XXVI Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2008

Sociedad de Biología de Cuyo-Ministerio de Salud Gobierno de Mendoza- Dirección de Investigación Ciencia y Técnica.

Effects of alliums on oxidative stress and inflammation in an experimental model of metabolic syndrome FCM. UN Cuyo. IMBECU-CONICET. Mendoza.  Dietary factors play a central role in prevention of cardiovascular disease. The aim was to evaluate the effect of allium consumption: garlic (G) and onion (O) extracts on blood pressure (BP), vascular remodeling and adipocytokines expression in an experimental model of metabolic syndrome (FFR). Fifty rats were randomly divided in 5 groups (n=10 in each group): Control (C), FFR (administration of 10% fructose solution as drinking water during a 14 wk protocol); FFR+G (150mg/kg/d), FFR+O (400mg/Kg/d), and FFR+T (1mM tempol, used as antioxidant control) during the last 8 weeks. Biochemical determinations, blood pressure (BP), oxidative stress assay, histological and optic microscopy analysis and western blot analysis were performed. FFR increased their BP, glycemia, triglyceridemia and insulin (p<0.05 v C). G, O and T treatment only prevent the BP increase. NAD(P)H oxidase activity in aorta and plasma TBARS levels increased in the FFR. Groups receiving allium extracts and tempol did not show changes in oxidative status. Significant increase in vascular remodeling was observed in mesenteric and heart arteries from FFR, compared to other groups. Adipocitokyne expression in mesenteric adipose tissue did not vary. Data provide evidence indicating that alliums consumption prevents the increase in BP, the oxidative stress, and vascular remodeling in and experimental model of metabolic syndrome.