Inhibition of goiter growth and of cyclic AMP formation in rat thyroid by 2-iodohexadecanal.

THOMASZ L; OGLIO MR; DAGROSA A; JAHN GA; KRAWIEC L; PIGNATARO O; SARTORIO G; PISAREV M; JUVENAL G

New York, EEUU

Congreso; 78ava Reunión Anual de la American Thyroid Association; 2007

American Thyroid Association

Introduction: Thyroid autoregulation has been related to intraglandular content of an unknown putative iodocompound. The thyroid is capable of producing different iodolipids such as 6-iodo-deltalactone (IL) and 2-iodohexadecanal (IHDA). Data from different laboratories have shown that these iodolipids inhibit several thyroid parameters. IL has an antigoitrogenic action but no data are about the action of IHDA. Objectives: to study the action of IHDA on MMI-induced goiter. Results: Administration of MMI to rats during 10 days increases thyroid weight by 86%. This effect was significantly inhibited by the simultaneous injection of 10 µg/day of IL (45 % inhibition) or IHDA (48%, p