IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
INDUCTION OF HYPOTHALAMIC THYROID RECEPTORS EXPRESSION BY THE SUCKLING STIMULUS
Autor/es:
PENNACCHIO GE; PARRILLA J; JAHN GA; VALDEZ SR; SOAJE M
Lugar:
Maipu
Reunión:
Congreso; XXXI Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2013
Institución organizadora:
Sociedad de Biología de Cuyo
Resumen:
During lactation there are adaptations that enhance the metabolic efficiency with the aim to ensure the adequate fulfillment of the nutrient needs of the newborn. Suckling is an important stimulant of PRL secretion and food intake, and thyroid status is involved in the metabolic adaptations to lactation. Our objective is to attempt to determine whether circulating thyroid hormones and the hypothalamic response capacity to thyroid hormones are modulated by the suckling stimulus. For this, we determined serum PRL, T3 and T4 by RIA and the expression of thyroid hormone receptors isoforms (TRα1, TRα2, TRβ1, TRβ2) and of two members of the family of nuclear receptor co-regulators (NCOR1 y NCOR2) in medial basal hypothalamus (MBH) by real time quantitative RT-PCR in mid-lactating Sprague Dawley rats separated from their pups for 12 h and subsequently suckled for 0 (S), 2 (S/s2h) or 4 h (S/s4h). Two or 4 h suckling increased significantly PRL, T3 and T4 release (p