Cardiac oxidative modifications in fructose overload rats: prevention by (-)-epicatechin.

PIOTRKOWSKI BARBARA; VALERIA CALABRÓ; GIOVANNA ASCHETTINO; LAURA FISCHERMAN; MARCELA VAZQUEZ-PRIETO; MONICA GALLEANO; CESAR G. FRAGA

Alba

Congreso; Oxygen Club of California World Congress 2012; 2012

Oxygen Club of California

The purpose of this study was to evaluate the effects of (-)-epicatechin (EC) supplementation on oxidative modifications in the heart of rats subjected to a model of metabolic syndrome. Male Sprague-Dawley rats were divided into three groups and received for 8 w: i) control diet and tap water (C); ii) control diet and 10% (w/v) fructose in the drinking water (F), and iii) 10% (w/v) fructose in the drinking water, and the diet supplemented with EC (20 mg/kg BW/d) (F+EC). Systolic blood pressure in rats with fructose overload was significantly higher than in control rats and EC prevented that increase (C=130±4; F=142±3*; F+EC=133±3; *p