FAT INTAKE PROMOTES CHANGES IN SPERMATOGENESIS

PIETROBON ELISA; MARTÍNEZ VICTORIA; SAEZ LANCELLOTTI TANIA ESTEFANÍA; VINCENTI AMANDA EDITH; CUELLO DARIO; FORNES MIGUEL

San Luis

Congreso; Reunión científica anual de la Sociedad de Biología de Cuyo.; 2012

The intracellular cholesterol regulation depends on a balance between: produced de novo and incorporated by specific receptors. A dietary imbalance –unknown at testicular level- may trigger apoptosis and proliferation arrest. Detection in the structure of testicular tissue alterations in spermatogenesis and / or spermiogenesis, lipid accumulation and apoptosis under different diets were performed. Adult male rabbits (New zealand) were used feeding with specific diets: control group (commercial diet, Gepsa®), hypercholesterolemic (HC = commercial diet plus bovine grease) and protected group with olive oil (OO = commercial diet plus virgin olive oil). The number of apoptotic cells (detected by Tunel techniques), decreased proliferation (differential cell counted) and structural abnormalities (transmission electron microscopy) were evident in the HC while in AO reversed. The mechanism underline at the cellular/testicular tissue level is not defined yet but structural evidence showed the Golgi-Acrosomal complex disorganized accompanied by an altered manchette. These abnormalities could trigger apoptosis and/or inhibit cell divisions.