VITAMIN D-RAAS CONNECTION: AN INTEGRATIVE STANDPOINT INTO CARDIOVASCULAR AND NEUROINFLAMMATORY DISORDERS

RAÚL SANZ; WALTER MANUCHA; FERES MOCAYAR; FERES MOCAYAR; VIRNA MARTÍN GIMENÉZ; LEÓN FERDER; VIRNA MARTÍN GIMENÉZ; LEÓN FERDER; RAÚL SANZ; WALTER MANUCHA

CURRENT PROTEIN AND PEPTIDE SCIENCE

Bentham Science Publishers

Año: 2020 vol. 21 p. 948 - 954

1389-2037

Neuroinflammation is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors in the central nervous system. Besides, the present article condenses the evidence supporting the link between vitamin D and the RAAS in hypertension and neuroinflammation. Vitamin D deficiency is highly prevalent in the world, and the rising prevalence of neuroinflammatory diseases and associated pathologies such as hypertension around the world justifies the urgent need of searching new and more effective therapeutic methods that could be related to RAAS modulation and vitamin D levels management.