THE ADMINISTRATION OF TELLERIUM TO RAT MOTHERS IN THE LACTATION PERIOD AFFECTS THE NATURAL LATERALIZED EXPLORATION AND SOCIAL ACTIVITY OF THEIR OFFSPRING MATURING RATS.

ALVAREZ TORO, EDGARDO, RATTI, SILVIA G.;SACCHI, OSVALDO

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2020 vol. 80 p. 103 - 103

0025-7680

THE ADMINISTRATION OF TELLURIUM TO RATMOTHERS IN THE LACTATION PERIOD AFFECTS THENATURAL LATERALIZED EXPLORATION AND SOCIALACTIVITY OF THEIR OFFSPRING MATURING RATS.Edgardo O. Alvarez Toro (Lab Epig Neuropsicofarm Exptl,FCVet, UCCSL,San Luis), Silvia G. Ratti (Lab Epig NeuropsicofarmExptl, FCM, UCCSL, San Luis, FCM UNCuyo, Mendoza),Osvaldo Sacchi (IMBECU-CONICET, Mendoza)Previous evidence from our laboratory showed that intact rats subjectedto a chronic administration (51 days) of non-toxic K2TeO3(Te, 0.39μg/L) the normal response of lateralized exploration andsocial activity of the offspring maturing rats was affected. In order toinvestigate if these modified behaviours were due to Te prolongedexposition, in the present work a short treatment (21 days) of Te administrationto mother rats in the lactation period was applied. At 30day-old, all offspring were tested in the Double Lateral Hole BoardLabyrinth (DLHB), and 24 hours later in the Intruder to Resident Test(IRT), as previously described. The following groups were formed:Control rats (n=20) and Te-treated rats (n=18). Results found in theDLHB showed that Control rats had a left biased exploration (70±5.3Vs. 45.5±4.1 Counts/3 min; left Vs right, p < 0.01), while Te-treatedrats showed no side preference exploration (49±3.9 Vs 47.5±6.3C/3min; Left Vs right, n.s.). In the IRT, control rats showed a latencyto confront the intruder rat of 9±2.6 C/2min; while in the Te-treatedrats latency was 32±8.3 C/2min, statistically different from Controlgroup (p < 0.02). Duration of social interaction in the Control groupwas 93±5.5 C/3min; while in the Te-treated rats was 73±3.6 C/3min,statistically lower from Control group (p < 0.01). In conclusion, resultssuggest that it is not necessary a prolonged administration ofTe in order to affect the exploratory and social activity in the offspringrats.