High Intake of Maternal Milk Prevents the Development of Mammary Cancer in Pups Maintaining Elevated Ingestion of Saturated Fats

SASSO, CORINA VERÓNICA; CAMPO VERDE ARBOCCÓ, FIORELLA; CARÓN, RUBÉN WALTER; ZYLA, LEILA ESTER; PISTONE CREYDT, VIRGINIA; SANTIANO, FLAVIA ELIANA; BRUNA, FLAVIA ALEJANDRA; LÓPEZ FONTANA, CONSTANZA MATILDE; SASSO, CORINA VERÓNICA; CAMPO VERDE ARBOCCÓ, FIORELLA; CARÓN, RUBÉN WALTER; ZYLA, LEILA ESTER; PISTONE CREYDT, VIRGINIA; SANTIANO, FLAVIA ELIANA; BRUNA, FLAVIA ALEJANDRA; LÓPEZ FONTANA, CONSTANZA MATILDE

Biomedical Research Group

Biomedical Research Group

Lugar: Westchester; Año: 2019 vol. 16 p. 1 - 9

2574-1241

Environmental factors in early life have a strong implication on the development of diseases in adult life. Nutritional changes during perinatal life can modify the susceptibility to develop breast carcinoma. In this report, we studied the influence of a diet high in saturated fat in the development of breast cancer, in rats that maintained a differential milk intake during their lactation period. We also analysed the possible mechanisms involved in tumor development. We compared mammary carcinogenesis in Sprague-Dawley adult rats, grown-up in litters of 3 (L3) or 8 (L8) pups per mother during lactation to induce a differential consumption of maternal milk. After weaning all pups were fed witha diet high in saturated fat ?HF? (40% of energy from lipids) until adulthood. At 55 days of age, the animals were treated with a single dose of dimethylbenzanthracene to study tumor latency, incidence and progression. Histological and immunohistochemical studies were performed. We observed that animals that maintained high milk intake (L3) had lower mammary cancer incidence than animals that maintained lower milk consumption (L8; P