Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies

FERES MOCAYAR; WALTER MANUCHA; DIEGO KASSUHA; DIEGO KASSUHA; VIRNA M. MARTÍN GIMÉNEZ; LEÓN FERDER; VIRNA M. MARTÍN GIMÉNEZ; LEÓN FERDER; FERES MOCAYAR; WALTER MANUCHA

Annals of Pharmacology and Pharmaceutics

Remedy Publications

Lugar: California; Año: 2019 vol. 4 p. 1 - 10

2573-6051

The endocannabinoid system is closely related to the central nervous system and exerts a promisingtherapeutic potential on it and other systems such as the cardiovascular, mainly through its neuromodulatory, neuroprotective and neuroinflammatory effects. For this reason, when designingnew treatments for different relevant pathologies such as hypertension, it is necessary to take intoaccount the side effects that such therapies can cause at the neurological level. Deeping knowledge of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary. The present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized.