Effect of chronic aspirin administration on an experimental model of metabolic syndrome.

RENNA NF; VAZQUEZ M; LAMA C; GONZALEZ S; MIATELLO RM

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Blackwell publisher

Año: 2009 vol. 36 p. 162 - 168

0305-1870

1. This study examined the effect of chronic administration of aspirin on metabolic and cardiovascular parameters, in fructose-fed rats (FFR), an experimental model of the metabolic syndrome. 2. Chronic treatment with aspirin partially reverted the increment in systolic blood pressure and normalized relative heart weight and vascular remodelling of renal and carotid arteries measured as ratio of lumen diameter to medial thickness in FFRs. 3. Additionally, aspirin administration completely reverted glucose intolerance and decreased the oxidative status that characterize FFR model by diminishing plasma thiobarbituric acid reactive substances (TBARS) levels and aortic NAD(P)H-oxidase activity. 4. Prevention of oxidative stress and vascular remodelling in FFR may contribute to the protective properties attributed to aspirin in the treatment of metabolic syndrome.