IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
ALTERATIONS ON A KEY NEPHROGENIC/CARDIOGENIC GENE EXPRESSION LINKED TO HYPERTENSION DEVELOPMENT
Autor/es:
RAÚL SANZ; LUCIANA MAZZEI; WALTER MANUCHA
Revista:
Clínica e Investigación en Arterioesclerosis
Editorial:
Barcelona : Ediciones Doyma S.A.
Referencias:
Lugar: Barcelona; Año: 2020 vol. 32 p. 70 - 78
ISSN:
0214-9168
Resumen:
The elevation of blood pressure produces specific organic lesions, including kidney and cardiac damage. On the other hand, the cardiovascular disease usually leads to the development of hypertension. Thus, hypertension could be both a cause and a consequence of cardiovascular disease. Previous studies linked the lack of nitric oxide to cardiovascular abnormalities, including hypertension, arteriosclerosis, myocardial infarction, cardiac hypertrophy, diastolic heart failure, and reduced endothelium-derived hyperpolarizing factor responses, with shorter survival. The lack of this gas also leads to renal/cardiac abnormalities. It is widely known that nephrogenic deficiency is a risk factor for kidney disease. Besides, recent evidence suggests that alterations in WT-1, a key nephrogenic factor, could contribute to hypertension development. Moreover, some genes involved in the development of hypertension depend on WT-1.This knowledge makes essential to investigate and understand the mechanisms regulating the expression of these genes during renal/cardiac development and hypertension. As a consequence, the most in-depth knowledge of the complex etiopathogenic mechanism responsible for the hypertensive disease will allow us to propose novel therapeutic tools.