Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarction Implicancias del factor de transcripción WT1 asociado al remodelado cardiaco patológico postinfarto miocárdico

MANUCHA, WALTER; MANUCHA, WALTER; MAZZEI, LUCIANA; MAZZEI, LUCIANA; SANZ, RAÚL LELIO; SANZ, RAÚL LELIO

Clinica e Investigacion en Arteriosclerosis

Elsevier Doyma

Año: 2018 p. 121 - 127

0214-9168

New advances in the treatment of acute myocardial infarction involve novel signaling pathways and cellular progeny. In this sense, regeneration is a novel tool that would contribute to post-infarction physiological ventricular remodeling. More specifically, re-expression of the WT1 transcription factor in the myocardial wall by ischemia and infarction would be related to the invasion of cells with the capacity for regeneration. This mechanism seems not to be sufficient to restore muscle cells and lost vessels entirely. Of particular interest, the presence of the heat-shock response protein 70 (Hsp70) and its interaction with the vitamin D receptor would modulate the expression of WT1 positively. In this context, it is proposed that the activation of vitamin D receptors associated with Hsp70 could favor physiological cardiac remodeling and reduce the progression to heart failure.