IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
ANANDAMIDE AND ENDOCANNABINOID SYSTEM: AN ATTRACTIVE THERAPEUTIC APPROACH FOR CARDIOVASCULAR DISEASE
Autor/es:
SANDRA NORIEGA; WALTER MANUCHA; DIEGO KASSUHA; DIEGO KASSUHA; VIRNA M. MARTÍN GIMÉNEZ; VIRNA M. MARTÍN GIMÉNEZ; LUCÍA FUENTES; LUCÍA FUENTES; SANDRA NORIEGA; WALTER MANUCHA
Revista:
Therapeutic Advances in Cardiovascular Disease
Editorial:
SAGE journals
Referencias:
Lugar: Londres; Año: 2018 vol. 12 p. 177 - 190
ISSN:
1753-9447
Resumen:
Nowadays cardiovascular disease, are not therapeutically well controlled and have become one of the main causes of morbidity and mortality worldwide. Current therapies are insufficient to achieve the appropriate treatment to stop their progression. There are several limitations such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction -not always beneficial- and that for years has gone unnoticed is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.