IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes.
Autor/es:
ALVAREZ EO; BEAUQUIS J; REVSIN Y; BANZAN AM; ROIG P,; DE NICOLA AF; SARAVIA F
Revista:
BEHAVIOURAL BRAIN RESEARCH
Editorial:
Elsevier
Referencias:
Lugar: Alemania; Año: 2009 vol. 198 p. 224 - 230
ISSN:
0166-4328
Resumen:
Type 1 diabetes (TID) is accompanied by a "diabetic encephalopaty" including hypersensitivity to stress, increased risk of stroke, dementia and cognitive impairment. In previous works we reported several brain alterations, including a strong decrease in hippocampal proliferation and survival in both spontaneous streptozotocin-induced models of experimental TID. The aim of this study was to explore in streptozotocin-treated mice and other parameters associated to mild neurodegeneration in the dentate gyrus and the potential correlation with behavioural changes. The neurogenesis status, measured by doublecortin (DCX) expression, showed an important decline in the number of positive cells in the subgranular zone (SGZ). However, neuronal migration was not affected. We found a marked enhancement of intracellular lipofuscin deposits, characteristic of increased oxidative stress and aging in both, the hilus and the SGZ and granular cell layer (GCL). Diabetic mice showed a significant impairment in learning and memrory tests, exhibiting a higher latency to show an escape response and a poorer leraning efficiency of an active avoiding response compared to control mice.Both, exploratory and non-exploratory activities in a conflictive environment in the asymmetric elevated plus maze were not affected by the diabetic condition. In conclusion, experimental diabetes showed clear signs of changes in the dentate gyrus, changes similar to those present in the aging process. Correlatively, these alterations were in line with a reduced performance in learning and memory tests. The mechanism that could potentially link neural and behavioural disturbances is not yet fully comprehended.