NITRIC OXIDE: A NEW POSSIBLE BIOMARKER IN HEART FAILURE? RELATION WITH PULMONARY HYPERTENSION SECONDARY TO LEFT HEART FAILURE

JULIA FAUSTI; WALTER MANUCHA; JUAN PABLO CALVO; ADOLFO JUAN GAMBARTE; ROBERTO BONAFEDE; SONIA PUEBLA

Clínica e investigación en aterosclerosis

Barcelona : Ediciones Doyma S.A.

Año: 2017 vol. 29 p. 120 - 126

Heart failure (HF) is a growing medical problem and it is of interest to study new biomarkers for better characterization. In this sense, we evaluated nitric oxide (NO), reactive oxygen species (ROS), NADPH and superoxide dismutase (SOD), and its possible predictive value in patients with HF. In addition, we studied potential differences between patients with and without secondary pulmonary hypertension (SPH), considered to have a worse prognosis. In HF, we demonstrated a significant decrease of NO and SOD, whereas ROS and NADPH were increased. These results agree with the pathophysiological changes characteristic of HF. We also demonstrated in patients with HF and SPH that NO and SOD were decreased relative to HF without SPH, whereas ROS and NADPH were increased. Therefore, our results suggest that NO, ROS, NADPH and SOD, could be considered as possible markers in HF and could also characterize patients with SPH.