IMBECU 20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
Impact of TNF-Receptor p55 deficiency in the susceptibility of C57BL/6 mice to the infection with Leishmania (Leishmania) amazonensis
Autor/es:
SALOMON MC; GEA S.; CARGNELUTTI DE; CUELLO-CARRIÓN F.D.; SCODELLER EA; CELEDON V; DI GENARO MS
Revista:
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Editorial:
SCIENTIFIC COMMUNICATIONS INT LTD
Referencias:
Lugar: Taiwan; Año: 2016 vol. 49 p. 271 - 275
ISSN:
1684-1182
Resumen:
The TNF is involved in host resistance to several intracellular pathogens. Although the critical role of TNFRp55 in Leishmania (Leishmania) major infection has been demonstrated, the impact of TNFRp55 deficiency on L. (L.) amazonensis infection has not been explored. L. (L.) amazonensis-infected TNFRp55 -/- mice fail to resolve lesions, while C57BL/6 wild type mice completely heal. The susceptibility of the TNFRp55 -/- mice was characterized by higher lesion size and histopathology damage in comparison with the wild type. A markedly increased of the splenic index was observed in the TNFRp55 -/- mice after fifteen weeks of infection. These results show that in the absence of TNFRp55, L. (L.) amazonensis-infected knockout mice fail to resolve lesions, while wild type mice completely heal.
