El efecto ansiolítico de testosterona en ratas macho no se debe a la aromatización de estrógeno: evidencias preliminares

YUNES, R; BOULIN, F; CABRERA, R

Revista Médica Universitaria

Año: 2007 vol. 3 p. 22 - 31

1669-8991

It has been reported that testosterone (T) and its metabolites dihydrotestosterone and 3œ-androstanediol exhibit anxiolytic properties. However, and since T is also usually aromatized to estradiol (E2), it has not been ruled out the possibility of E2 being responsible for the aforementioned effect, at least partially. In this report, by using intact and castrated male rats, with or without E2 or T replacement, we could conclude that the anxiolytic effect is not due to E2 but to T and, eventually its non aromatizable metabolites.