IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
HSP70 FAMILY IN THE RENAL INFLAMMATORY RESPONSE
Autor/es:
WALTER MANUCHA
Revista:
Inflammation & Allergy - Drug Targets.
Editorial:
Bentham Science Publishers
Referencias:
Año: 2014 vol. 13 p. 235 - 240
ISSN:
1871-5281
Resumen:
Heat shock proteins (HSP) is a shock induced family of proteins, which most prominent members are a group of molecules dedicated to maintaining the function of other proteins. Interestingly, and after being exposed to heat shock typical proinflammatory agonists modify the heat shock-induced transcriptional program and expression of HSP genes, suggesting a complex reciprocal regulation between the inflammatory pathway and that of the heat shock response. The specific task of Heat shock protein 70 (Hsp 70), the most widespread and highly conserved HSP, is to protect against inflammation through multiple mechanisms. So, the expression of immune reactivity to Hsp70 in the kidney could be cause for hypertension. Hsp70 modulates inflammatory response, as well as down-regulates the nuclear factor kappa-light-chain-enhancer of activated B cells. Also, a decreased expression of renal Hsp70 may contribute to activate the toll-like receptor 4-initiating inflammatory signal pathway. In addition, several studies have revealed that Hsp70 is involved in the regulation of Angiotensin II, a peptide with pro-inflammatory activity. Increased inflammatory response is generated by nicotinamide adenine dinucleotide phosphate oxidase, following activation by Angiotensin II. Interestingly, Hsp70 protects the renal epithelium by modulation of nicotinamide adenine dinucleotide phosphate oxidase, a fundamental step in the pro-inflammatory mechanism. This article aims to summarize our understanding about possible mechanisms improving the renal inflammatory process linked to Hsp70 expression. Finally, from a therapeutic point of view, the notion of antiinflammatory tools regulating Hsp70 could directly affect the inflammatory renal disease.