28) Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice.

PELEG-RAIBSTEIN D, HAUSER J, LLANO LOPEZ LH, FELDON J, GARGIULO PA, YEE B.

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2012

0033-3158

Rationale The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphetamine. Prior repeated exposures to amphetamine also disrupt PPI even when the drug is not present during test, suggesting that a sensitized mesolimbic dopamine system?inducible even by a single exposure to amphetamine?might be responsible. However, this causative link has been challenged by inconsistent efficacy between different amphetamine pre-treatment regimes, which all robustly sensitize the behavioral response to amphetamine.