PARTICIPATION OF THE CD44 RECEPTOR AND GENES IMPLICATED IN HYALURONAN METABOLISM IN COGNITIVE DEFICIT OF CHRONICALLY STRESSED MICE.

ALEJANDRO MORONI; MICAELA CASTRO; ANA MARIA GENARO; LAURA ALANIZ; LAURA PALUMBO

Mar del Plata

Congreso; Reunión anual de Sociedades Biocientíficas 2019; 2019

Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad de Farmacología Experimental (SAFE), la Sociedad Argentina de Biología (SAB), la Sociedad Argentina de Protozoología (SAP), la Asociación Argentina de Nanomedicinas (NANOMED-ar), La Asociaci

We demonstrated that chronic mild stress (CMS) induce cognitive deficit and a decrease in hippocampal neurogenesis in Balb/c mice. Furthermore, the glycosaminoglycan hyaluronan (HA) is a key component of the extracellular matrix (ECM) in the brain. HA plays an important role in physiological and pathological process, like neuronal development, synaptic plasticity and neurodegeneration. HA is synthesized by HA synthases (HAS1-3) and degraded by hyaluronidases (Hyal1-3). CD44 is the main receptor for HA and it is related to neurological disorders. The aim of this work was to study the effects of the CMS on learning and memory in female C57BL/6J CD44+/- and the expression of CD44 and genesimplicated in the metabolism of HA in the hippocampus of female Balb/c mice. We found a decrease in learning and memory in CD44+/- CMS mice respect to WT and CD44+/- control mice in Y-maze (% spontaneous alternation: p