INVESTIGADORES
ALANIZ Laura Daniela
artículos
Título:
Altered hyaluronan biosynthesis and cancer progression: an immunological perspective
Autor/es:
LAURA ALANIZ; MARIANA GARCÍA; MIGUEL RIZZO; FLAVIA PICCIONI; GUILLERMO MAZZOLINI
Revista:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Año: 2009 p. 1538 - 1546
ISSN:
1389-5575
Resumen:
Hyaluronan is a glycosaminglycan present in practically all tissues as
an important component of the extracellular matrix. In spite of its
apparent simple chemical structure, hyaluronan is a molecule with
multiple and complex physiogical and pathological functions, Hyaluronan
is able to regulate a variety of biological processes such as cellular
growth, migration, differentiation and inflammation, not only in normal
but also in cancer tissues. Besides, increasing evidence suggests
hyaluronan as a potent modulator of immune responses which supports a
potential role of this molecule in cancer immunotherapy.