INCITAP   20787
INSTITUTO DE CIENCIAS DE LA TIERRA Y AMBIENTALES DE LA PAMPA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Antitumor effects of glycosylated 4-methylumbelliferone in a murine model of fibrosis associated- hepatocellular cancer
Autor/es:
MALVICINI M; BRECCIA J; WEIZ G; MAZZOLINI G; RODRIGUEZ M; MOLEJON MI
Reunión:
Congreso; Reunion Bienal 2019; 2019
Resumen:
Most of drugs lack of systems that direct them to the target tissues. In this way, a large part of drugs that remains in the bloodstream increases the secondaries effects in patients. The glycosylation of molecules is an interesting strategy for drug delivery to the specific target. The compound 4-methylumbelliferone (4Mu) was described as inhibitor of the synthesis of hyaluronic acid and anticancer agent for hepatocellular carcinoma (HCC) associated with advanced fibrosis. The aim of this work was to evaluate the antitumoral effect of the glycosylated 4Mu.