Model for deconstruction of the non-carcinogenic risk of metals and metalloids in food

P,M. DEMETRIO; F. ÁLVAREZ; F.CORA JOFRE; S. MEDICI; M.B. ROMERO; M. GERPE; S.O. DEMICHELIS; D. NASSINI; L.N. CHIODI BOUDET; L.P. FERNÁNDEZ; M. PRIMOST; A.V.VOLPEDO; J.S. FUCHS; A.E. BOHÉ; L. FERNÁNDEZ; S. MISCORIA; M. SAVIO

Santiago

Congreso; SETAC (Society of Environmental Toxicology and Chemistry), Latin America,14th Biennial Meeting.; 2021

SETAC Latinoamerica

Heavy metals and metalloids are persistent and bioaccumulativepollutants, therefore, they are present in food and are toxic to human. Todetermine what are the allowable intake values of an element for a givenhuman population, dietary habits constitute an issue to solve; inaddition, it is necessary to establish national regulatory standards. Inorder to assess the acceptable limit values of element concentration for agiven food, a non-traditional risk model has been developed, based onthe reference dose as admissible daily intake for each contaminant,following a classical non-carcinogenic risk model in a backward sense.A characteristic annual dish must be proposed from the intake/year percapita, as a percentage of the total meal for each food item. Dataincluded in the proposed dish are obtained from the national domesticconsumption. Different exposure pathways have to be considered basedon the human food web. Furthermore, it is necessary to characterize thediet throughout different regions in the country under assessment.Published element concentrations from different food chain are assessedand integrated in a unique annual dish, including wild animals(terrestrial and aquatic), farming animals (aquaculture, poultry andlivestock), animal products, crops, processed grains and beverages.According to available data, different distribution models are suggestedto be applied to assess the concentration of elements in food. Metalportion absorbed by each food web level is estimated from absorptionfactors published. The total annual intake of one element is calculatedfrom the relative contribution of each diet item, considering each foodchain when it is necessary. An estimation of non-carcinogenic risk couldbe done according to weight, age, and sex. This model could be used to SETAC Latin America 14th Biennial Meeting Abstract Book 41establish an acceptable maximum intake from a specific food origin,according to their element content. Besides, it is a preliminary attempt tobuild a model to integrate human health risks from different pollutantsassociated with ingesta;[1] [2] with the aim of reducing [3] uncertaintiesand increasing strengths, turning as a utility tool to decision makers toelaborate of guidelines values. The methodology presented wasdeveloped by the RSA-CONICET research group, contributing toestablish food guidelines for metals and metalloids in the productive chain