IIB   20738
INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
BACTERICIDAL AND CYTOTOXIC ACTIVITIES OF POLYPHENOL EXTRACTS FROM ANDEAN AND INDUSTRIAL POTATOES
Autor/es:
DAMIANO RB; SILVEYRA MX; LANTERI ML; ANDREU AB
Lugar:
Mar del Plata
Reunión:
Encuentro; XI Encuentro Biólogos En Red; 2016
Institución organizadora:
Biologs en red
Resumen:
Potatoes (Solanum tuberosum) are a good source of dietary antioxidant polyphenols. This study investigated the in vitro antioxidant, bactericidal and cytotoxic activities of the polyphenols present in tubers of three Andean and one industrial potato varieties. Both phenolic acids content and antioxidant activity were higher in skin extracts than in flesh ones, being chlorogenic acid (CGA) the most abundant phenolic acid. Extracts from Andean Moradita flesh and from industrial Summerside skin showed bactericidal activity against E. coli ATCC 25922. Both extracts have high absolute content of CGA, presence of ferulic acid and absence of pigmentation. In contrast, no bactericidal effects were found against pathogenic E. coli O157. Positive control with gentamicin and commercial CGA resulted in inhibition of bacterial growth. We also showed that all extracts exerted a dose-dependent cytotoxic effect in SH-SY5Y human neuroblastoma cells. Skin extracts were more potent than flesh ones, and commercial CGA treatments compromised SH-SY5Y cell viability. On the whole, results demonstrate that extracts with similar phenolic acid level and/or composition do not exert similar antioxidant and/or biological activity. These findings suggest that the activity of potato extracts is a combination of various bioactive compounds and contribute to the revalorization of potato as a functional food.