Monte Carlo simulation of proton track structure in biological matter

QUINTO, MICHELE A.; MONTI, JUAN M.; WECK, PHILIPPE F.; FOJÓN, OMAR A.; HANSSEN, JOCELYN; RIVAROLA, ROBERTO D.; SENOT, PHILIPPE; CHAMPION, CHRISTOPHE

EUROPEAN PHYSICAL JOURNAL D

SPRINGER

Lugar: Berlin; Año: 2017 vol. 71

1434-6060

Abstract: Understanding the radiation-induced effects at the cellular and subcellular levels remains crucial for predicting the evolution of irradiated biological matter. In this context, Monte Carlo track-structure simulations have rapidly emerged among the most suitable and powerful tools. However, most existing Monte Carlo track-structure codes rely heavily on the use of semi-empirical cross sections as well as water as a surrogate for biological matter. In the current work, we report on the up-to-date version of our homemade Monte Carlo code TILDA-V ? devoted to the modeling of the slowing-down of 10 keV?100 MeV protons in both water and DNA ? where the main collisional processes are described by means of an extensive set of ab initio differential and total cross sections. Graphical abstract: [Figure not available: see fulltext.].