Environmental pesticide exposure modulates cytokines, arginase and ornithinedecarboxylase expression in human placentaVanina

VANINA BULGARONI, PAOLA LOMBARDO, VALERIA RIVERO-OSIMANIB, BERTA VERA, LAURA DULGERIAND,FABIO CERBÁND, VIRGINIA RIVEROD, GLADIS MAGNARELLIB,, NATALIA GUI?NAZÚA,

REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.)

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2013 vol. 39 p. 23 - 32

0890-6238

tTo evaluate the cytokine balance and enzymatic alterations induced by environmental pesticide expo-sure during pregnancy, this transversal study explored placentas derived from non-exposed women(control group-CG), and from women living in a rural area (rural group-RG), collected during inten-sive organophosphate (OP) pesticide spraying season (RG-SS) and during non-spraying season (RG-NSS).The exposure biomarkers blood cholinesterase and placental carboxylesterase (CaE) were significantlydecreased in RG-SS. Among the cytokines studied IL-8, IL-6, TNF, IL-10, TGF and IL-13, the expres-sion frequency of IL-13 increased in RG-SS. Arginase and ornithine decarboxylase (ODC) enzymes wereinduced in syncytiotrophoblast and endothelial cells. Interestingly, the decrease in CaE activity was asso-ciated with arginase and ODC activity induction. These findings suggest that environmental pesticideexposure impacts the placenta by increasing the expression frequency of the anti-inflammatory cytokineIL-13, which may be related to the up-regulation of enzymes implicated in tissue repair.