PROBIEN   20416
INSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS, BIOTECNOLOGIA Y ENERGIAS ALTERNATIVAS
Unidad Ejecutora - UE
artículos
Título:
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
Autor/es:
VERA B, SANTA CRUZ S AND MAGNARELLI G G
Revista:
REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.)
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012
ISSN:
0890-6238
Resumen:
Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmentalorganophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact ofOP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy womenwho live in agricultural farms. Samples were collected during the pulverization period (PP) and recessperiod (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that womenwere exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increasedand the phosphatidylethanolamine content decreased in the light mitochondrial fraction while totalcholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggestrepair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicologicalimplications and thus entail potential risks to damage fetal growth and development.