INIBIOMA   20415
INSTITUTO DE INVESTIGACIONES EN BIODIVERSIDAD Y MEDIOAMBIENTE
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of dorso-medial telencephalic adult-born neurons on Active Avoidance learning in a teleost fish model
Autor/es:
MAZZITELLI FUENTES, LAURA SOLEDAD; CRICHIGNO, SONIA ALEJANDRA; AUSAS, MARIA SOLEDAD; ROMÁN, FERNANDA RUTH; MONGIAT, LUCAS ALBERTO
Lugar:
Mar del Plata
Reunión:
Congreso; XXXII Congreso Anual SAN 2017; 2017
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Teleosts exhibit adult neurogenesis throughout their brain, making them an excellent model to study the way in which network remodeling by adult neurogenesis shapes brain function. Cognitive ability was assessed by Active Avoidance (AA) paradigm in adult rainbow trout (Oncorhynchus mykiss). Learning performance correlated with neuronal activity in dorso-medial (Dm) telencephalic region. To investigate the relationship between Dm neuronal addition and cognitive performance we attempted to behaviorally modulate adult neurogenesis. For this purpose, adult trouts were injected intraperitoneally with bromodeoxyuridine (BrdU), and then housed either in an Enriched Environment (EE) or in Social Restriction (SR) for 4 weeks. In order to avoid treatment-related stress on learning tasks, individuals from both groups were transferred to a common barren tank for 2 more weeks, until sacrifice. On week 6, AA learning, short and long-term memory performance were assessed (STM & LTM: 1h and 24h post-training, respectively). Fish reared in EE showed a better learning, STM and LTM performance, in terms of latency and % of avoidance, in contrast to SR fish. Proliferation, cell survival and neuronal activity analysis are currently being assessed.