INIBIOMA 20415
INSTITUTO DE INVESTIGACIONES EN BIODIVERSIDAD Y MEDIOAMBIENTE
Unidad Ejecutora - UE
artículos
Título:
Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool
Autor/es:
TROCHINE A; CREEK D; FARAL-TELLO P; BARRETT MP; ROBELLO C
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2015 vol. 59 p. 2921 - 2925
ISSN:
0066-4804
Resumen:
Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor.After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.
