Early memory impairment in altered fasting glucose patients?

CANAL, MARÍA PILAR; BAEZ, MARÍA VERÓNICA; CARUSO, ORNELA AZUL; CARUSO, ORNELA AZUL; MUNNER, MARIANA GABRIELA; MUNNER, MARIANA GABRIELA; CANAL, MARÍA PILAR; BAEZ, MARÍA VERÓNICA

Congreso; XXXV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2020

Sociedad Argentina de Investigación en Neurociencias

Type 2 Diabetes (DBT2) is a metabolic syndrome characterized by an increase in glucoseand insulin blood levels (hyperglycemia and hyperinsulinemia respectively). This syndromeis closely related to neurodegeneration and central nervous system damage .Prediabetes 2 (preDBT) is considered to be a step before DBT2, with glucose levelsintermediate between normal and DBT levels. However, it is not well understood if preDBTper se, or the progression to DBT2, could cause cognitive decline. Because of this, wedecided to investigate whether this damage can be found in patients with altered fastingglucose (AG), the first clinical demonstration of preDBT. For this reason, AG and controlpatients were asked to perform the Rey?Osterrieth complex figure test (ROCF), to discardany impairment in graphical performance and procedural memory; the SAGE test, to assessdifferent stages of early memory impairment; and the evocation of a list of words, to evaluatelong term memory (LTM). We found that there were no significant differences between AGand control groups in the ROCF test or in LTM. However, AG patients showed a poorperformance in the SAGE test, due to an impairment in short term memory (STM), attention,construction of simple forms and associative memories. Furthermore, performances in theSAGE test correlate in a negative form with the increase in glucose levels .These preliminary results lead us to hypothesize that cognitive impairment could start duringAG period..