IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Iron markers of neurocognitive development of prenatally stressed infants
Autor/es:
CAMILA ZELGERT; LOBMAIER, SILVIA M.; PETER ZIMMERMANN; FRASCH, MARTIN G.; RITIKA SHARMA; ANTONELLI, MARTA C.
Reunión:
Jornada; MGC Science Day. Technical University of Munich.; 2020
Resumen:
Background: Matching the raising need of iron during pregnancy it is important to prevent an impairment of the growing child due to iron deficiency. We aimed to assess the influence of prenatal maternal stress (PS) on the sensitive fetal iron metabolism. We hypothesized that PS impacts fetal serum iron markers. Methods: Prospective case-control study with 728 women screened during third term of pregnancy at the Department of Obstetrics and Gynaecology at ?Klinikum rechts der Isar? of the Technical University of Munich (TUM) located in Munich using Cohen Perceived Stress Scale 10 (PSS-10) questionnaire. N=79 patients with PSS-10 ≥ 19 were classified as SG and n=85 women with PSS-10 < 19 served as control group (CG) additionally matched with SG patients for gestational and maternal age at study entry and parity. Further data was collected using sociodemographic and Prenatal Distress Questionnaire (PDQ). Fetal electrocardiograms were recorded by a transabdominal ECG (taECG). BPRSA analysis of the coupling between maternal (mHR) and fetal Heart Rate (fHR) was proceeded and fetal stress index (FSI) calculated. Cord blood serum hepcidin, transferrin and iron were determined. Maternal hair cortisol was measured at birth. Results: 728 of 2000 women returned the PSS-10 questionnaire. 20,7 % showed a PSS-10 score ≥ 19. 79 women formed the SG and n=85 served as CG. We found no significant differences regarding maternal hair cortisol and iron parameters between the groups. In SG FSI was significantly higher in comparison to CG [0.4 ((-0.2)-0.7)), respectively 0.02 ((-0.4)-0.4) p=0.028] and shows a positive correlation to PDQ (0.18, p=0.028). Conclusion: Influence of general maternal stress during third term of pregnancy on iron metabolism is questionable. Prenatal maternal stress affects the coupling between maternal and fetal heart rate detectable non-invasively a month prior to birth. It is assumed that maternal stress is mostly due to pregnancy specific anxiety