Dopaminergic and Noradrenergic systems control protein synthesis during behavioural tagging process in memory reconsolidation

SCHROEDER, MATÍAS NICOLÁS; MONCADA, DIEGO; GRISPUN, MARTÍN; FULLIO, CAMILA L.

Congreso; XXXIV Reunión Anual SAN 2019; 2019

Our recent findings show that memory reconsolidationrelays on a behavioral tagging process. That is to say, the event whichtriggers memory reconsolidation induces both the setting of a tag, which laterdecides where memory will be stored, and the synthesis of plasticity relatedproteins (PRPs) that will be captured at the tagged sites for memory reconsolidationto occur. Our current work focuses on identifying the neurotransmitter systemsand the brain structures that regulate the synthesis of PRPs.Using the spatial object recognition (SOR) task, we showthat the infusion of the D1/D5-dopaminergic receptor antagonist SCH23390, orthe β-adrenergic receptor antagonist propranolol, 15 min before thereactivation of SOR memory induced long-term retrograde amnesia. Interestingly,the exploration of a novel open-field within a restricted time window overcamethe amnesic effect of both antagonists, rescuing memory reconsolidation. Inaddition, the electrical stimulation of the ventral tegmental area (VTA) or thelocus coeruleus (LC), 60 min before the reactivation session, also preventedthe amnesic effect of emetine infusion in either CA1 or dentate gyrus,respectively.In summary, our results suggest that the VTA and theLC act over the hippocampus via the D1/D5-dpaminergic and the β-adrenergicreceptors, thus regulating the synthesis of those proteins required duringmemory reconsolidation.