IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Vertebrates axes are maternally biased.
Autor/es:
CASTRO COLABIANCHI, AITANA MANUELA; LÓPEZ, SILVIA LILIANA; FRANCHINI, LUCÍA F.; RUBINSTEIN, MARCELO
Lugar:
Buenos Aires
Reunión:
Congreso; Xth Latin American Society for Developmental Biology (LASDB) Meeting.; 2019
Institución organizadora:
Latin American Society for Developmental Biology (LASDB)
Resumen:
It is considered that the radial symmetry around the polarized Animal-Vegetal axis of the Xenopus egg is broken after fertilization by relocation of dorsal determinants. This results in local stabilization of maternal β-catenin and the induction of the dorsal signaling centers that lead to the establishment of the Spemann-Mangold?s Organizer (Gerhart et al., 1989) (Gilbert, 2014). It is generally accepted that the signaling pathways activation that defines the Anterior-Posterior, Dorsal-Ventral and Left-Right axes in vertebrates takes place during zygotic transcription, and that the differential activation of genes in different groups of cells defines pluripotent embryonic cell populations with different prospective fates, thus establishing the embryonic body axes.Here we show the first results in vertebrate models that indicate that molecules previously shown to be involved in patterning the embryonic body axes or in decisions in the embryonic/ab-embryonic axes like Notch1 (Rayon et al., 2014) (Castro Colabianchi et al., 2018) are asymmetrically distributed in the unfertilized egg. We think that this primary asymmetry might lead to the asymmetric inheritance of cellular components of the unfertilized egg by the early embryo, and perhaps, they would have some participation in differential signaling in the derived embryonic cell populations.