IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
“NCAM, an alternative signaling receptor for GDNF in hippocampal and cortical neurons”
Autor/es:
PARATCHA G
Lugar:
Huerta Grande, Cordoba, Argentina
Reunión:
Congreso; IRCN-First Joint Meeting of the Argentine Society for Neuroscience (SAN) and the Argentine Workshop in Neurosciences (TAN); 2009
Institución organizadora:
Sociedad Argentina de Neurociencias y Taller de Neurociencias
Resumen:
NCAM, an alternative signaling receptor for GDNF in hippocampal and cortical neurons.Gustavo Paratcha, Instituto de Biología Celular y Neurociencias Prof. E. De RobertisFacultad de Medicina, UBA.Glial cell line-Derived Neurotrophic Factor (GDNF) signals through the canonical signaling receptor Ret and a glycosyl-phosphatidylinositol-anchored co-receptor GFRa1. Signaling by GDNF has been shown to be more complex than originally assumed. The discrepant expression between GFRa and Ret has suggested the existence of alternative signaling-transducing GDNF receptors. In recent years, we show that the Neural Cell Adhesion Molecule (NCAM) can function as a novel signaling receptor for GDNF ligands.  Association of NCAM with GFRa1, downregulates NCAM-mediated cell adhesion and promotes high-affinity binding of GDNF to NCAM, resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking Ret. In hippocampal and cortical neurons, GDNF stimulates axonal growth and presynaptic maturation via binding to NCAM and independently of Ret. This evidence reveals an alternative pathway for GDNF signaling that does not require the Ret receptor.