IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
DIFFERENT RESPONSES IN ANXIOGENIC-LIKE BEHAVIOR AND MOTOR COORDINATION IN CB1+/- AND CB1-/- MICE
Autor/es:
CALTANA, LAURA; BRUSCO, ALICIA ; SORIANO, DELIA
Lugar:
Córdoba
Reunión:
Congreso; SAN 2019; 2019
Institución organizadora:
Sociedad Argentina de Neurosciencia
Resumen:
Given that the CB1 receptor (CB1) has been associated to mood and behavior, theaim of this study was to evaluate the effects of CB1 deficiency in behavioralparadigms of anxiety and depression.Male CB1 knockout mice (CB1-/-), heterozygous CB1+/- and CB1+/+ were testedin behavioral paradigms. Open field (OF), elevated plus maze (EPM), light-darkbox (LDB) and rotarod tests were carried out to evaluate anxiety-like behavior andmotor coordination. Novelty-suppressed feeding (NSF), sucrose splash and forcedswimming test (FST) were performed to evaluate depression-like behavior.In EPM and LDB, the number of entries and time spent in the aversive area waslower in CB1-/- but not in CB1+/-. In OF, EPM and LDB, explorative parameterswere decreased only in CB1-/-. In the rotarod test, CB1-/- did not improve motorperformance after training while CB1+/- improved it after repetitive training.NSF showed no differences in intake latency but a reduction in CB1-/- food intake.The sucrose splash test revealed a reduction in latency to groom and time ofgrooming in CB1-/-, and the FST showed longer immobilization during the lastperiod of time.In conclusion, CB1-/- exhibited deficits in motor coordination, anxious anddepressive behavior. However, CB1+/- showed alterations in motor coordinationbut not in anxiety-like behavior.These results could explain the role of CB1 in behavioral parameters, which maycorrelate with CB1 polymorphism observed in depressive patients.