IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Dopaminergic and Noradrenergic systems control protein synthesis during the behavioral tagging process underlying memory reconsolidation.
Autor/es:
FULLIO, CAMILA; GRINSPUN, MARTÍN; SCHROEDER, MATÍAS NICOLÁS; MONCADA, DIEGO
Lugar:
Meisdorf
Reunión:
Workshop; What makes synapse plastic? Plasticity mechanisms and failures revisited; 2019
Institución organizadora:
LIN
Resumen:
Our recent findings show that memory reconsolidation relays on a behavioral tagging process. That is to say, the event which triggers memory reconsolidation induces both the setting of a tag, which later decides where memory will be stored, and the synthesis of plasticity related proteins (PRPs) that will be captured at the tagged sites for memory reconsolidation to occur. Our current work focuses on identifying the neurotransmitter systems and the brain structures that regulate the synthesis of PRPs.Using the spatial object recognition (SOR) task, we show that the infusion of the D1/D5-dopaminergic receptor antagonist SCH23390, or the β-adrenergic receptor antagonist propranolol, 15 min before the reactivation of SOR memory induced long-term retrograde amnesia. Interestingly, the exploration of a novel open-field within a restricted time window overcame the amnesic effect of both antagonists, rescuing memory reconsolidation. In addition, the electrical stimulation of the ventral tegmental area (VTA) or the locus coeruleus (LC), 60 min before the reactivation session, also prevented the amnesic effect of emetine infusion in either CA1 or dentate gyrus, respectively.In summary, our results suggest that the VTA and the LC act over the hippocampus via the D1/D5-dpaminergic and the β-adrenergic receptors, thus regulating the synthesis of those proteins required during memory reconsolidation.