IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Behavioral Tagging Is A General Mechanism Of Long-Term Memory Formation
Autor/es:
BALLARINI FABRICIO; ALEN NADIA; MARTÍNEZ M. CECILIA; MONCADA DIEGO; VIOLA HAYDÉE
Lugar:
Huerta Grande, Cordoba, Argentina
Reunión:
Taller; IRCN; 2009
Resumen:
<!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;
mso-font-charset:0;
mso-generic-font-family:roman;
mso-font-pitch:variable;
mso-font-signature:-1610611985 1107304683 0 0 415 0;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;
mso-font-charset:0;
mso-generic-font-family:swiss;
mso-font-pitch:variable;
mso-font-signature:-520092929 1073786111 9 0 415 0;}
@font-face
{font-family:RotisSemiSerif;
panose-1:0 0 0 0 0 0 0 0 0 0;
mso-font-alt:"MS Mincho";
mso-font-charset:128;
mso-generic-font-family:roman;
mso-font-format:other;
mso-font-pitch:auto;
mso-font-signature:0 134676480 16 0 131072 0;}
@font-face
{font-family:"\@RotisSemiSerif";
panose-1:0 0 0 0 0 0 0 0 0 0;
mso-font-charset:128;
mso-generic-font-family:roman;
mso-font-format:other;
mso-font-pitch:auto;
mso-font-signature:0 134676480 16 0 131072 0;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{mso-style-unhide:no;
mso-style-qformat:yes;
mso-style-parent:"";
margin-top:0cm;
margin-right:0cm;
margin-bottom:10.0pt;
margin-left:0cm;
line-height:115%;
mso-pagination:widow-orphan;
font-size:11.0pt;
font-family:"Calibri","sans-serif";
mso-ascii-font-family:Calibri;
mso-ascii-theme-font:minor-latin;
mso-fareast-font-family:Calibri;
mso-fareast-theme-font:minor-latin;
mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;
mso-bidi-font-family:"Times New Roman";
mso-bidi-theme-font:minor-bidi;
mso-fareast-language:EN-US;}
.MsoChpDefault
{mso-style-type:export-only;
mso-default-props:yes;
mso-ascii-font-family:Calibri;
mso-ascii-theme-font:minor-latin;
mso-fareast-font-family:Calibri;
mso-fareast-theme-font:minor-latin;
mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;
mso-bidi-font-family:"Times New Roman";
mso-bidi-theme-font:minor-bidi;
mso-fareast-language:EN-US;}
.MsoPapDefault
{mso-style-type:export-only;
margin-bottom:10.0pt;
line-height:115%;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 3.0cm 70.85pt 3.0cm;
mso-header-margin:36.0pt;
mso-footer-margin:36.0pt;
mso-paper-source:0;}
div.WordSection1
{page:WordSection1;}
-->
It is currently proposed that memories
are stored by stable changes
in synaptic weight modifying the
activity of specific neuronal circuits.
Then, synapses activated by learning will
require the supply of new
plasticity-related proteins (PRPs) for
the formation of long term memory
(LTM). In consequence, there should be
a mechanism limiting the action
of PRPs to recently activated synapses.
To address this biological problem,
the synaptic tagging and capture
hypothesis postulated that a transient
local synaptic tag is set at those
recently activated synapses where PRPs
will be specifically captured. Using
two different behavioral events, it was
possible to separate tagging from PRP synthesis.
We demonstrated by using
one hippocampus-dependent learning task
that, in rats subjected to weak
training protocols that induce only
short term memory, LTM is promoted
and formed when training sessions took
place in contingence with a novel
experience occurring during a critical
time windows around training. The
process named behavioral tagging
requires protein synthesis induced by
novelty. Here, we decided to study
whether this process can be observed
using other hippocampus-dependent
(spatial object recognition) and an
hippocampus-independent (conditioned
taste aversion) tasks. We found
that behavioral tagging operates in
different hippocampus- and cerebral
cortex-dependent learning tasks with
different behavioral features,
suggesting that it represents a general
mechanism in LTM formation.
These findings show the first
comprehensive set of evidences indicating the
existence of a behavioral tagging
process, sharing synaptic tag properties
like transient lifetime, independence
of protein synthesis and specificity of
input