IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Early Impairments in Learning and Memory of the McGill-R-Thy1-APP transgenic rat model of AD
Autor/es:
M.F. ACUTAIN; T. GONZALEZ GARELLO; A.C. CUELLO; A. DE TOMAS LIORO; E.E. KORNSIUK; D.A. JERUSALINSKY; M.C. CERCATO; M.P. CANAL; M.V. BAEZ
Lugar:
CABA
Reunión:
Simposio; Alzheirmer´s Asociation International Conference (AAIC) Satellite Symposium; 2018
Resumen:
The McGill-R-Thy1-APP Tg rat (Leon et al. 2010), at variance with most mouse transgenic (Tg) models, has a minimal genetic burden, as it carries a single transgene. The expression of a modified variant of human APP751 containing both the Swedish and Indiana mutations, leads to slow-progressing amyloid pathology associated with cognitive impairments. In homozygous (Ho) Tg rats, human Aβ accumulates intra-neuronally from one week postnatal and develops into extracellular amyloid pathology by 6-9 months of age. On the other hand, McGill-R-Thy1-APP hemizygous (He) rats do not develop extracellular plaques even in 20 months old animals. In these rats.Therefore, this Tg rat model offers a singular opportunity for testing learning and memory abilities at early AD stages. He and Ho young adult McGill-R-Thy1-APP Tg rats have been characterized in different behavioral task and long term memory (LTM) was assessed only in the MWM task. In this paradigm, He and Ho rats exhibit different performances at different ages. For this reason, in searching what are the earliest deficits in LTM acquisition and consolidation in this animal model, we decided to analyze He rats performance at different ages, compared with their wild type littermates in various tasks, as habituation to an OF, inhibitory avoidance to a mild foot-shock, new object location and new object recognition