IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
SPACED LEARNING AND THE MECHANISMS OPTIMIZING MEMORY FORMATION
Autor/es:
BUDRIESI, P; H. VIOLA; LOPES DA CUNHA, P; TINTORELLI, R; CORREA, J
Lugar:
La Havana
Reunión:
Congreso; II Congreso Panamericano de Fisiología; 2019
Resumen:
The superiority of spaced learning over the massed one is afundamental fact in the formation of long-term memories(LTM). The objective of this work is to study the cellularprocesses and the temporal demands of this phenomenon,using weak spatial object recognition (wSOR) and weakinhibitory avoidance (wIA) learning tasks.We observed SORLTMpromotion when two identical wSOR, which individuallyinduced short-term memories but did not form LTM, werespaced by an inter-trial interval (ITI) ranged between 15 minto 7 h. The promoting effect was dependent on neuralactivity, protein synthesis and MAPKs activity in thehippocampus. Also, two identical wIA training sessionsspaced by 4 h, promoted IA-LTM. In contrast, when wecombined one wIA with a wSOR, neither of the two tasksformed LTMs. We concluded that in order to form a LTMafter a weak learning, it is necessary to perform a retrainingprotocol to the same learning task within a restrictedtemporal window. Based on the "behavioral tagging"hypothesis which postulates the existence of a tag inducedby learning that utilizes proteins to form LTM, we suggestthat the neural contacts stimulated by the first trainingsession are re-tagged by retraining. Moreover, afterretraining, the intracellular mechanisms triggered by bothsessions could be added, reaching the threshold for proteinsynthesis required for memory consolidation. On the otherhand, when animals trained in two different and weak tasks,the processes triggered by them would not meet the spatialrequirements necessary to form LTM.