IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Novelty improves LTM after reconsolidation through a behavioural tagging process
Autor/es:
MONCADA, DIEGO; RABINOVICH, ORLANDI IVAN ; HERBITI, FERMIN ; BALLARINI, FABRICIO; FULLIO, CAMILA L
Lugar:
Mar del Plata
Reunión:
Congreso; XXXII Congreso Anual SAN; 2017
Institución organizadora:
Sociedad Argentina en Neurociencias (SAN)
Resumen:
Novelty improves LTM after reconsolidation through a behavioral tagging process. Camila Fullio, Ivan Rabinovich Orlandi, Fermin Herbiti, Fabricio Ballarini and Diego Moncada  Last year we introduced that memory reconsolidation occurs through a behavioral tagging process. We demonstrated this showing that reconsolidation blockade, inducedby the infusion of the protein synthesis inhibitor emetine (EME) after retrieval, in eitherthe spatial object recognition (SOR) and the inhibitory avoidance (IA) tasks, can be rescued by previous explorationto a novel open field (OF) that provides the proteins required for the process to occur.Here we stepped forward by studying how does the novel experience, in the context of memory reactivation, affects LTM performance after reconsolidation.We observed that SOR reconsolidation established a different memory with the new position of the object during the reactivation session. Also, EME infusion after memory reactivation blocked the reconsolidation inducing amnesia for the original and the new memory.Interestingly, the exploration of a novel OF 1h before memory reactivation rescued the LTM for both the original and the new position of the object. Besides, the same exploration performed before a reactivation session in normal conditions (without EME) improvedthe LTM after the reconsolidation.Moreover, this effect depended on protein synthesis induced by the novel experience. Similar effects were observed in the IA task.As whole, our results show that experiences close to memory reactivation can improve LTM performance, by taking advantage of the behavioral tagging processunderlying the reconsolidation.