IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Female distinctive behavioural profile in the VPA rat model: diving in the gender differences of autism spectrum disorders.
Autor/es:
MALLEVILLE-CORPA MJ; REINES A; MOLINA M; UCCELLI NA; CODAGNONE MG; TRAETTA ME
Lugar:
Mar del Plata
Reunión:
Congreso; Congreso 2016 de la SAIC; 2016
Institución organizadora:
SAIC
Resumen:
Autism spectrum disorders AS are a group of severe neurodevelopmental disabilities ith an early onset and no clear neurobiological basis. AS are characterized by pervasive impairments in social interactions, deficits in verbal and nonverbal communication, and stereotyped behaviours. Although incidence of AS is four times higher in boys than in girls, gender differences have been out of scope. The rat model of autism induced by prenatal exposure to alproic Acid A presents in males, behavioural and neuroanatomical alterations similar to those seen inautistic patients. Since gender differences in the A rat model have not been addressed, the aim of this or as to characterize the behavioural profile off emale A rats FA. At early postnatal days , FA shoed groth and maturational deficits similar to the ones exhibited by male A rats A.FA not only displayed delayed eye opening but a loer body eight. They alsoshoed altered negative geotaxis, higher latencies to nest seeing response and a deficit in simming performance. Similar to A, FA matched control performance by the end of the early postnatal period. Hoever, at , FA behaviour differed from the one of A. Although FA shoed reduced interactions in the social play behaviour test, they exhibited distinctive pinning features. Contrary to Athat shoed an exploratory deficit and increased stereotypical activities, FAmatched control female behaviour. otably, at this stage , FA hippocampal cytoarchitecture alterations resemble those seen in A. To sum up, FA exhibit a distinctive behavioural profile characterized by a maturational delay and strong social impairment but normal exploratory and stereotypical activity. nderstanding gender differences in AS can lead the ay to unravel the basis of social impairment and to come up ith novel therapeutic targets for these disorders.