IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Memory deficits in 13 month old wild type and in transgenic McGill-R-Thy1-APP rats with brain amyloidosis
Autor/es:
FILIPPÍN, FEDERICO; AGUIRRE, ALEJANDRA; JERUSALINSKY, DIANA; BAEZ, MARÍA V.; CUELLO, CLAUDIO; CERCATO, MAGALÍ; JOSIOWICZ, ALEJANDRO; KORNISIUK, EDGAR
Lugar:
Mar del Plata
Reunión:
Congreso; Congreso FALAN 2016; 2016
Institución organizadora:
Federation of Latin American and Caribbean Societies
Resumen:
P { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 10); line-height: 115%; widows: 2; orphans: 2; }P.western { font-family: "Calibri",serif; font-size: 11pt; }P.cjk { font-family: "Calibri"; font-size: 11pt; }P.ctl { font-family: "Calibri"; font-size: 11pt; }Therat model of brain amyloidosis McGill-R-Thy1-APP(TG) bearing the transgene of human amyloid precursor protein withtwo familial Alzheimer?s disease (AD) mutations (Leon et al.,2010), shows earlyamyloidbeta peptide (Abeta) intracellular accumulation in cortical andhippocampal pyramidal cells. Homozygous rats exhibit extracellularAbetadeposits as happens in AD, while hemizygous present features thatwould correspond with an earlier step of AD without extracellularAbeta accumulation.Wehave characterized cognitive features of hemizygous TGs in parallelwith their wild genotype littermates (WT) to discriminate putativeage deficits from those due to amyloidosis. 13month old TG and WT ratswere evaluated in open field (OF), step-throughinhibitory avoidance (IA), object location (OL) and objectrecognition (OR) tasks;short-term (ST) and long-term (LT) performances were assessed.Therewere no differences between WT and TG rats in OF explorationparameters, showing that both were able to habituate to theenvironment for the ST and LT. TGs seemed to be unable to learn theIA task, while WT rats performed well for the ST and LT. Neither WTsnor TGs seemed to discriminate OL at variance with younger animals.WTs performed well in the ST and LT for OR, while TGs only showed STmemory for OR.Hence,this TG rat would be an appropriate model for investigating earlysteps of AD and for evaluating potential therapies to repaircognitive dysfunctions in this sort of pathologies.