IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Requirement of an early activation of BDNF/cFos cascade in the retrosplenial cortex for the persistence of a longlasting aversive memory
Autor/es:
KATCHE C
Reunión:
Congreso; 2nd FALAN Congress; 2016
Resumen:
During the past few years there has been growing interest in the role of the retrosplenial cortex (RSC) in memory processing. However, little is known about the molecular changes that take place in this brain region during memory formation. In the present work, we studied the early posttraining participation of RSC in the formation of a longlasting memory in rats. We found an increase in cFos levels in the anterior part of the RSC (aRSC) after inhibitory avoidance (IA) training. Interestingly, this increase was associated with memory durability, since blocking cFos expression using specific antisenseoligonucleotides (ASO) impaired longlasting retention 7 days after training without affecting memory expression 2 days after training. In addition, we showed that BDNF is one of the upstream signals for cFos expression required for memory persistence, since blocking BDNF synthesis prevents IA training inducedincrease in cFos levels in aRSC and affects memory persistence. In addition, we found that injection of BDNF into aRSC around training was sufficient to establish a persistent memory and that this effect was prevented by cfos ASO infusion into the same structure. These findings reveal an early posttraining involvement of aRSC in the processing of a longlasting aversive memory.