IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
FIRST EVIDENCE Of BEHAVIORAL TAGGING ACTING IN MEMORY RECONSOLIDATION
Autor/es:
MONCADA, DIEGO; BALLARINI, FABRICIO; RABINOVICH ORLANDI, IVAN
Lugar:
Buenos Aires
Reunión:
Congreso; 2nd FALAN Congress; 2016
Institución organizadora:
FALAN
Resumen:
Behavioral tagging (BT) is a process underlying long-term memory (LTM) formation. It consists on two parallel and complementary mechanisms: the setting of a learning tag (LT) that defines where a memory will be stored, and the synthesis of proteins (PRPs), that once captured at tagged sites, stabilize the mnemonic trace into a LTM. Thus as long as PRPs and LTs coexist in the same substrate, proteins can be supplied by any event. Interestingly, BT also underlies memory extinction; one of the processes triggered by retrieval. But, retrieval can also trigger reconsolidation. As one its principal functions would be memory updating, it is worthwhile asking if the new mnemonic engram, set during reconsolidation, is established through a BT process.To study this, we combined protocols capable of inducing reconsolidation in the inhibitory avoidance and spatial object recognition tasks, with pharmacological interventions and the exploration to a novel open field (OF). We show that reconsolidation blockade, induced by the inhibition of protein synthesis during retrieval, can be rescued by previous exploration to a novel OF that provides the PRPs. Moreover, other amnestic evens such as the inhibition of PKA or the exploration to a novel arena after retrieval cannot be rescued by providing PRPs through OF exploration. As a whole, our result show for the first time that BT underlies memory reconsolidation.