MMN distributed sources. Evidence from human intracranial recordings.

BLENKMANN ALEJANDRO; PHILLIPS HOLLY; CHENNU SRIVAS; ROWE JAMES; MURAVCHIK CARLOS; KOCHEN SILVIA; BEKINSCHTEIN TRISTAN

Leipzig,

Conferencia; 7th Mismatch Negativity Conference; 2015

University of Leipzig

In order to investigate MMN sources we recorded electrocorticography (ECoG) and/or Stereo-electroencephalography (SEEG) in 14 patient candidates for epilepsy surgery, covering temporal, parietal, occipital and frontal cortices.We used three paradigms to evoke MMN potential.1- An auditory MMN paradigm (Näätänen et al. 2004), alternating standard tones with deviant tones. Performed by 13 patients.2- Four series of 5 complex tones (Bekinschtein et al, 2009). Two using the same 5 sounds and two with the final sound swapped. Performed by 6 patients. 3- A modification of the previous paradigm (Chennu et al 2013), where sequences were either monaural or interaural. Performed by 7 patients.Channels with epileptic activity or noise were discarded, and a total of 683 channels were analyzed. Local average reference was used to improve signal from local sources compared to distant ones. MMN potentials were analyzed with paired t-test (p