Retrosplenial cortex is necessary for consolidation and expression of object recognition memories

DE LANDETA, AB; MEDINA JH; KATCHE C

Congreso; XXX CONGRESO ANUAL SAN 2015 - 30 AÑOS; 2015

Over the last few years, the interest in the retrosplenial cortex (RSC) function on memory has increased. Recently, our laboratory has demonstrated that RSC is required for the formation, storage and expression of aversive memories using the inhibitory avoidance (IA) paradigm. Moreover, we have shown that the RSC and hippocampus (Hp) interact for longlasting IA memory storage. To further analyze the role of RSC in memory processing, we used two different variants of the object recognition paradigm to evaluate which components of the information are processed in RSC, one variant with spatial cues (SOR) to study ?where?, and a non-spatial task (Y-OR), to study ?what?. Inactivation of RSC immediately, but not 3 h after training, impaired memory consolidation tested 24 h later in both variants of the task. In addition, we found that inactivation of RSC 15 min before test at 24 h also impaired memory retrieval in both variants. On the contrary, we found no effect after inactivation of the hippocampus in the same conditions. These results indicate that RSC is involved in object recognition memory formation and expression, and it is processing different components of information to be store.