IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PERINATAL ASPHYXIA DETERIORATES SOCIAL INTERACTION IN RATS
Autor/es:
PABLO VAZQUEZ; CATALINA RICO; DIEGO COHON; ELENA PEÑA
Lugar:
Rio de Janeiro
Reunión:
Congreso; IBRO - 9th World Congress International Brain Research Organization; 2015
Institución organizadora:
International Brain Research Organization
Resumen:
Obstetrical complications, particularly in the case of perinatal asphyxia, can often induce lesions that, in the long-term, manifest as schizophrenia. In this study we analyzed the effect of perinatal asphyxia on social behavior, anxiety and locomotive activity in rats using two behavioral paradigms: the open field and the social interaction task. We analyzed the behavior of rats delivered by cesarean section and exposed to 19 min of asphyxia and compared the results with rats born by vaginal delivery and cesarean section. We also subjected a group of animals to asphyxia at low temperature to analyze the neuroprotective effects of hypothermia.The rats exposed to perinatal asphyxia showed deterioration in social interactions that manifested in a decrease in the total number of interactions. The quality of interaction was also diminished, with lower rates of play soliciting. We did not find significant changes in locomotive activity or in anxiety indicators in the open field task in this model, which involves severe/moderated asphyxia. The only  exception is  an increase in fecal depositions in the group born by c-section. When these parameter are analyzed in the social interaction task the result are the opposite, the asphyctic group shows an increase compared with the cesarean group. Other additional behavioral changes were caused by the c-section itself in the social interaction tasks including a preference for non rough play.  With the exception of the c-section rats, we observed a strong correlation between certain types of play, probably generated by an  interrelationship  between boxing and pinning. The group exposed to asphyxia under hypothermia trend to obtain higher scores than the asphyctic group in most of the parameters analyzed, yet the differences were not significant. We attribute this to the fact that social interaction is very vulnerable to neuronal damage.