IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
O-GlcNAcylation at promoters, nutrient sensors and transcriptional regulation.
Autor/es:
RANUNCOLO SM; GHOSH S; HANOVER JA; HART GW; LEWIS BA
Lugar:
Bethesda, Maryland
Reunión:
Encuentro; Principal Investigators Retreat 2014; 2014
Institución organizadora:
National Cancer Institute (NCI), National Institutes of Health (NIH)
Resumen:
Post-translational modifications play important roles in transcriptional regulation. Among the less understood PTMs is O-GlcNAcylation. Nevertheless, O-GlcNAcylation in the nucleus is found on hundreds of transcription factors and coactivators and is often found in a mutually exclusive ying-yang relationship with phosphorylation. O-GlcNAcylation also links cellular metabolism directly to the proteome, serving as a conduit of metabolic information to the nucleus. This review serves as a brief introduction to O-GlcNAcylation, emphasizing its important thematic roles in transcriptional regulation, and highlights several recent and important additions to the literature that illustrate the connections between O-GlcNAc and transcription.
