Role of the dorsal hippocampus in the acquisition, consolidation and retrieval of one-trial cocaine training memory

KRAMAR, CECILIA P.; BARBANO, M. FLAVIA; MEDINA, JORGE H.

Milan

Congreso; 9no Foro Europeo de Sociedades de Neurociencias; 2014

FENS

The role of the hippocampus in memory supporting associative learning between contexts and unconditioned stimuli is well documented. Hippocampal dopamine neurotransmission modulates synaptic plasticity and memory processing of fear-motivated and spatial learning tasks. Much less is known about the involvement of the hippocampus and its D1/D5 dopamine receptors in the acquisition, consolidation and retrieval of drug-associated experiences. Conditioned place preference (CPP) is one of the most studied animal models employed to demonstrate the rewarding properties of stimuli associated with a given context. We sought to determine, in rats, whether the hippocampus is involved in the modulation of different stages of memory processing for single trial cocaine CPP training.